Studies

Scientific TPS investigations at the Medical University of Vienna (Prof. Beisteiner) and international cooperation partners:

Transcranial Pulse Stimulation with Ultrasound in Alzheimer's Disease-A New Navigated Focal Brain Therapy.

Beisteiner R, Matt E, Fan C, Baldysiak H, Schönfeld M, Philippi Novak T, Amini A, Aslan T, Reinecke R, Lehrner J, Weber A, Reime U, Goldenstedt C, Marlinghaus E, Hallett M, Lohse-Busch H.
Adv Sci (Weinh). 2019 Dec 23;7(3):1902583.
DOI: 10.1002/advs.201902583

View study as PDF

Treating the brain at the speed of sound

Beisteiner R, Lozano A
Brain Stimul. 2020 Jul-Aug;13(4):1087-1088.
doi: 10.1016/j.brs.2020.04.020. Epub 2020 May 6. PMID: 32387244

View study as PDF

Transcranial Ultrasound Innovations Ready for Broad Clinical Application

Beisteiner R, Lozano AM
Adv Sci (Weinh). 2020 Oct 27;7(23):2002026.
doi: 10.1002/advs.202002026. PMID: 33304757; PMCID: PMC7709976

View study as PDF

Transcranial ultrasound pulse stimulation reduces cortical atrophy in Alzheimer's patients: A follow-up study

Popescu T, Pernet C, Beisteiner R.
Alzheimers Dement (N Y). 2021 Feb 25;7(1):e12121.
DOI: 10.1002/trc2.12121

View study as PDF

First evidence of long-term effects of transcranial pulse stimulation (TPS) on the human brain

Matt E, Kaindl L, Tenk S, Egger A, Kolarova T, Karahasanović N, Amini A, Arslan A, Sariçiçek K, Weber A, Beisteiner R.
J Transl Med. 2022 Jan 15;20(1):26.
DOI: 10.1186/s12967-021-03222-5

View study as PDF

Transcranial Pulse Stimulation (TPS) - A highly focused brain stimulation therapy with 3D navigation.

Beisteiner R, Hallett M.
Clin Neurophysiol. 2022 Jan 31:S1388-2457(22)00145-6.
DOI: 10.1016/j.clinph.2022.01.127

View Study as PDF

Human Ultrasound Neuromodulation: State of the Art

Beisteiner R.
Brain Sci. 2022 Feb 1;12(2):208.
doi: 10.3390/brainsci12020208. PMID: 35203971; PMCID: PMC8870582

Link to study

Transcranial pulse stimulation (TPS) improves depression in AD patients on state-of-the-art treatment.

Matt E, Dörl G, Beisteiner R.
Alzheimers Dement (N Y). 2022 Feb 10;8(1):e12245.
DOI: 10.1002/trc2.12245

View study as PDF 

Effects of Transcranial Pulse Stimulation on Young Adults With Symptoms of Depression: A Pilot Randomised Controlled Trial Protocol.

Cheung T, Ho J, Yeung J, Fong LS, Fong K, Fong T, Kranz G, Beisteiner R, Cheng C.
Frontiers Neurol, 2022
DOI:10.3389/fneur.2022.861214

View study as PDF

Functional Specificity of TPS Brain Stimulation Effects in Patients with Alzheimer’s Disease: A Follow-up fMRI Analysis

Dörl G, Matt E, Beisteiner R.
Neurol Ther, 2022 Sep;11(3):1391-1398
DOI: 10.1007/s40120-022-00362-8. Epub 2022 May 28. PMID: 35633496; PMCID: PMC9338196.

View study as PDF

Evaluating the Safety and Efficacy of Transcranial Pulse Stimulation on Autism Spectrum Disorder: A Double-Blinded, Randomized, Sham-Controlled Trial Protocol

Cheung T, Ho YS, Fong KH, Lam YTJ, Li MH, Tse AC, Li CT, Cheng CP, Beisteiner.
Int J Environ Res Public Health. 2022 Nov 24;19(23):15614.
DOI: 10.3390/ijerph192315614. PMID: 36497688; PMCID: PMC9737330.

Link to study

Safety of Clinical Ultrasound Neuromodulation

Radjenovic S, Dörl G, Gaal M, Beisteiner R.
Brain Sci. 2022, 12, 1277.
DOI: 10.3390/brainsci12101277

Link to study

Effects of Transcranial Pulse Stimulation (TPS) on Adults with Symptoms of Depression-A Pilot Randomized Controlled Trial

Cheung T, Li TMH, Ho YS, Kranz G, Fong KNK, Leung SF, Lam SC, Yeung WF, Lam JYT, Fong KH, Beisteiner R, Xiang YT, Cheng CPW
Int J Environ Res Public Health. 2023 Jan 28;20(3):2333.
doi: 10.3390/ijerph20032333. PMID: 36767702; PMCID: PMC9915638

Link to study

Ultrasound Neuromodulation as a New Brain Therapy

Beisteiner R, Hallett M, Lozano AM
Adv Sci (Weinh). 2023 Mar 24:e2205634.
doi: 10.1002/advs.202205634. Epub ahead of print. PMID: 36961104

Link to study

Evaluating the efficacy and safety of transcranial pulse stimulation on adolescents with attention deficit hyperactivity disorder: Study protocol of a pilot randomized, double-blind, sham-controlled trial

Cheung T, Chau B, Fong KH, Lam JYT, Lo H, Li MH, Li AMMC, Beisteiner R, Lei S, Yee BK, Cheng CPW
Front Neurol. 2023 Mar 28;14:1076086.
doi: 10.3389/fneur.2023.1076086. PMID: 37056363; PMCID: PMC10086174

Link to study

Other scientific TPS investigations:

Comparison of Transcranial Focused Ultrasound and Transcranial Pulse Stimulation for Neuromodulation: A Computational Study

Truong DQ, Thomas C, Hampstead BM, Datta A.
Neuromodulation. 2022 Jun;25(4):606-613.
DOI:10.1016/j.neurom.2021.12.012. Epub 2022 Feb 4. PMID: 35125300.

View Study as PDF

Retrospective real-world pilot data on transcranial pulse stimulation in mild to severe Alzheimer's patients

Cont C, Stute N, Galli A, Schulte C, Logmin K, Trenado C, Wojtecki L.
Front Neurol. 2022 Sep 14;13:948204.
DOI: 10.3389/fneur.2022.948204. PMID: 36188380; PMCID: PMC9515314.

Link to study

Transcranial pulse stimulation in Alzheimer's disease

Chen X, You J, Ma H, Zhou M, Huang C.
CNS Neurosci Ther. 2023 Jul 20.
doi: 10.1111/cns.14372. Epub ahead of print. PMID: 37469252.

Link to study

Transcranial pulse stimulation in the treatment of mild neurocognitive disorders

Fong TKH, Cheung T, Ngan STJ, Tong K, Lui WYV, Chan WC, Wong CSM, Cheng CPW.
Ann Clin Transl Neurol. 2023 Aug 21.
doi: 10.1002/acn3.51882. Epub ahead of print. PMID: 37607114.

Link to study

The Emergence of Functional Ultrasound for Noninvasive Brain-Computer Interface

Zheng H, Niu L, Qiu W, Liang D, Long X, Li G, Liu Z, Meng L.
Research (Wash D C). 2023 Aug 15;6:0200.
doi: 10.34133/research.0200. PMID: 37588619; PMCID: PMC10427153.

Link to study